Publications 1971-2005
Albert Gjedde
October 26, 2005
Gjedde A, Crone C (1975) Induction processes in blood-brain transfer of ketone bodies during starvation. Am J Physiol 229: 1165-1169
Gjedde A, Hansen AJ, Siemkowicz E (1980) Rapid simultaneous determination of regional blood flow and blood-brain glucose transfer in brain of rat. Acta Physiol Scand 108: 321-330.
Gjedde A (1981) High- and low-affinity transport of D-glucose from blood to brain. J Neurochem 36: 1463-1471
Gjedde A, Crone C (1981) Blood-brain glucose transfer: Repression in chronic hyperglycemia. Science 214: 456-457
Gjedde A (1982) Calculation of glucose phosphorylation from brain uptake of glucose analogs in vivo: A re-examination. Brain Res 257: 237-274
Gjedde A, Diemer NH (1985) A double tracer study of the fine regional blood-brain glucose transfer in the rat by computer-assisted autoradiography (CAA). J Cereb Blood Flow Metab 5: 163-178.
Wong DF, Wagner HNJr, Tune LE, Dannals RF, Pearlson GD, Links JM, Tamminga CA, Broussole EP, Ravert HT, Wilson AA, Toung JKT, Malat J, Williams JA, O’Tuama LA, Snyder SH, Kuhar MJ, Gjedde A (1986) Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics. eScience 234: 1558-1563
Gjedde A, Reith J, Dyve S, Léger G, Guttman M, Diksic M, Evans AC, Kuwabara H (1991) dopa decarboxylase activity of the living human brain. Proc Nat Acad Sci USA 88: 2721-2725.
Zatorre R, Evans AC, Meyer E, Gjedde A (1992) Lateralization of phonetic and pitch discrimination in speech processing. Science 256: 846-849
Reith J, Benkelfat C, Sherwin A, Yasuhara Y, Kuwabara H, Andermann F, Bachneff S, Cumming P, Diksic M, Dyve S, Etienne P, Evans A, Lal S, Shevell M, Savard G, Wong D, Chouinard G, Gjedde A (1994) Elevated dopa decarboxylase activity in living brain of patients with psychosis. Proc Nat Acad Sci USA 91: 11651-11654.
Gjedde A, Crone C (1975) Induction processes in blood-brain transfer of ketone bodies during starvation. Am J Physiol 229: 1165-1169.
Gjedde A, Andersson J, Eklöf B (1975) Brain uptake of lactate, antipyrine, water and ethanol. Acta Physiol Scand 93: 145-149.
Gjedde A, Caronna JJ, Hindfelt B, Plum F (1975) Whole-brain blood flow and oxygen metabolism in the rat during nitrous oxide anesthesia. Am J Physiol 229: 113-118.
Gjedde A, Hindfelt B (1975) Whole-brain blood flow and oxygen metabolism in the rat after halothane anesthesia. Acta Anaesthesiol Scand 19: 310-315.
Gjedde A, de la Monte SM, Caronna JJ (1977) Cerebral blood flow and oxygen consumption in rat, measured with microspheres or xenon. Acta Physiol Scand 100: 273-281.
Gjedde A, Lockwood A, Duffy TE, Plum F (1978) Cerebral blood flow and metabolism in chronically hyperammonemic rats: Effect of an acute ammonia challenge. Ann Neurol 3: 325-330.
Gregoire NM, Gjedde A, Plum F, Duffy TE (1978) Cerebral blood flow and cerebral metabolic rates for oxygen, glucose, and ketone bodies in new-born dogs. J Neurochem 30: 63-69.
Gjedde A, Gundtoft O, Svane H (1978) Deep sedative hypothermia (in Danish: Dyb sedativ hypotermi). Ugeskr Læger 140: 1408-1411.
Gjedde A, Hansen AJ, Siemkowicz E (1980) Rapid simultaneous determination of regional blood flow and blood-brain glucose transfer in brain of rat. Acta Physiol Scand 108: 321-330.
Gjedde A (1980) Rapid steady-state analysis of blood-brain glucoser transfer in rat. Acta Physiol Scand 108: 331-339.
Hansen AJ, Quistorff B, Gjedde A (1980)
Relationship between local changes in cortical blood flow and
extracellular K
during spreading depression. Acta Physiol Scand 109: 1-6.
Gjedde SB, Gjedde A (1980) Organ blood flow rates and cardiac output of the BALB/c mouse. Comp Biochem Physiol 67A: 671-674.
Siemkowicz E, Gjedde A (1980) Post-ischemic coma in rat: Effect of different pre-ischemic blood glucose levels on cerebral metabolic recovery after ischemia. Acta Physiol Scand 110: 225-232.
Gjedde A, Rasmussen M (1980) Blood-brain glucose transport in the conscious rat: Comparison of the intravenous and intracarotid injection methods. J Neurochem 35: 1375-1381.
Gjedde A, Rasmussen M (1980) Pentobarbital anesthesia reduces blood-brain glucose transfer in the rat. J Neurochem 35: 1382-1387.
Hansen AJ, Gjedde A, Siemkowicz E (1980) Extracellular potassium and blood flow in the post-ischemic rat brain. Pflugers Arch 389: 1-7.
Gjedde A (1981) High- and low-affinity transport of D-glucose from blood to brain. J Neurochem 36: 1463-1471.
Gjedde A, Hansen AJ, Quistorff B (1981) Blood-brain glucose transfer in spreading depression. J Neurochem 37: 807-812.
Christensen TG, Diemer NH, Laursen H, Gjedde A (1981) Starvation accelerates blood-brain glucose transfer. Acta Physiol Scand 112: 221-223.
Gjedde A, Crone C (1981) Blood-brain glucose transfer: Repression in chronic hyperglycemia. Science 214: 456-457.
Lauritzen M, Jørgensen MB, Diemer NH, Gjedde A, Hansen AJ (1982) Persistent oligemia of rat cerebral cortex in the wake of spreading depression. Ann Neurol 12: 469-474.
Gjedde A (1982) Calculation of glucose phosphorylation from brain uptake of glucose analogs in vivo: A re-examination. Brain Res Rev 4: 237-274.
Siemkowicz E, Hansen AJ, Gjedde A (1982) Hyperglycemic ischemia of rat brain: The effect of post-ischemic insulin on metabolic rate. Brain Res 243: 386-390.
Gjedde A (1982) The blood-brain barrier is impermeable to metrizamide. Acta Neurol Scand 66: 392-395.
Font C, Garcia-Campos M, Hansen AJ, Siemkowicz E, Gjedde A (1982) Constantes de difusion de inositol en cerebro de ratas. Laboratorio (Granada) 73: 499-506.
Gjedde A, Diemer NH (1983) Autoradiographic determination of regional brain glucose content J Cereb Blood Flow Metab 3: 303-310.
Gjedde A, Christensen O (1984) Estimates of Michaelis-Menten constants for the two membranes of the brain endothelium. J Cereb Blood Flow Metab 4: 241-249.
Bech L, Diemer NH, Gjedde A (1984) The effect of metrizamide on regional brain glucose metabolism in the rat. Acta Neurol Scand 69: 249-253.
Gjedde A: (1984) On the measurement of glucose in brain. Neurochem Res 9: 1667-1671.
Gjedde A (1984) Blood-brain transport of galactose in experimental galactosemia. With special reference to the competitive interaction between galactose and glucose. J Neurochem 43: 1654-1662.
Wong D, Wagner HN, Dannals RF, Links JM, Frost JJ, Ravert HT, Wilson AA, Rosenbaum AE, Gjedde A, Douglass KH, Petronis JD, Folstein MF, Toung JKT, Burns HD, Kuhar MJ (1984) Effects of age on dopamine and serotonin receptors measured by positron tomography in the living human brain. Science 226: 1393-1396.
Gjedde A, Diemer NH (1985) A double tracer study of the fine regional blood-brain glucose transfer in the rat by computer-assisted autoradiography (CAA). J Cereb Blood Flow Metab 5: 163-178.
Gjedde A, Wienhard K, Heiss W-D, Kloster G, Diemer NH, Herholz K, Pawlik G: (1985) Comparative regional analysis of 2-fluorodeoxyglucose and methylglucose uptake in brain of four stroke patients. J Cereb Blood Flow Metab 5: 282-289.
Andersen A, Waaben J, Husum B, Voldby B, Bødker A, Hansen AJ, Gjedde A (1985) Non-pulsatile cardiopulmonary bypass disrupts the flow-metabolism couple in brain. J Thorac Cardiovasc Surg 40: 570-579.
Bech L, Diemer NH, Gjedde A (1985) Metabolic effect of topical application of metrizamide to rat brain cortex. Acta Neurol Scand 72: 427-431.
Wong DF, Gjedde A, Wagner HNJr: (1986) Quantification of neuroreceptors in the living human brain. I: Irreversible binding. J Cereb Blood Flow Metab 6: 137-146.
Wong DF, Gjedde A, Wagner HNJr, Dannals RF, Douglass KH, Links JM, Kuhar MJ (1986) Quantification of neuroreceptors in the living human brain. II: Inhibition studies of receptor density. J Cereb Blood Flow Metab 6: 147-153.
Fuglsang A, Lomholt M, Gjedde A (1986) Blood-brain transfer of glucose and glucose analogs in newborn rats. J Neurochem 46: 1417-1428.
Kretzschmar R, Landgraf R, Gjedde A, Ermisch A (1986) Vasopressin binds to microvessels from rat hippocampus. Brain Res 380: 325-330.
Nedergaard M, Gjedde A, Diemer NH (1986) Focal ischemia of the rat brain: Autoradiographic determination of cerebral glucose utilization, glucose content and blood flow. J Cereb Blood Flow Metab 6: 414-424.
Wong DF, Wagner HNJr, Links JM, Kuhar MJ, Gjedde A (1986) Human brain receptor distribution. Science 232: 1269-1271.
Wong DF, Wagner HNJr, Tune LE, Dannals RF, Pearlson GD, Links JM, Tamminga CA, Broussole EP, Ravert HT, Wilson AA, Toung JKT, Malat J, Williams JA, O’Tuama LA, Snyder SH, Kuhar MJ, Gjedde A (1986) Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics. Science 234: 1558-1563.
Reith J, Ermisch A, and Gjedde A (1986) Saturable vasopressin retention in hippocampal endothelium and in non-BBB brain regions (pineal and pituitary gland s). Wiss. Z. Karl Marx Univ. 36: 87-90.
Reith J, Ermisch A, Diemer NH, Gjedde A (1987) Saturable retention of vasopressin by hippocampus vessels in vivo, associated with inhibition of blood-brain transfer of large neutral amino acids. J Neurochem 49: 1471-1479.
Nedergaard M, Gjedde A, Diemer NH (1987) Hyperglycemia protects against neuronal injury around experimental brain infarcts. Neurol Res 9: 241-244.
Redies C, Diksic M, Evans AC, Gjedde A, Yamamoto YL (1987) Double-label autoradiographic deoxyglucose method for sequential measurement of regional cerebral glucose utilization. Neurosci 22: 601-619.
Brøndsted HE, Gjedde A (1988) Measuring brain glucose phosphorylation with labeled glucose. Am J Physiol : E443-E448.
Rahbek Sørensen H, Husum B, Waaben J, Andersen K, Andersen LI, Gefke K, Kaarsen AL, Gjedde A (1988) Brain microvascular function during cardiopulmonary bypass. J Thorac Cardiovasc Surg 94: 727-732.
Redies C, Diksic M, Collier B, Gjedde A, Thompson CJ, Gauthier S, Feindel WH (1988) Influx of a choline analog to dog brain measured by PET. Synapse 2: 406-411.
Waaben J, Husum B, Hansen AJ, Gjedde A (1989) Local cerebral blood flow and glucose utilization during hyperventilation and adenosine-induced hypotension in the rat. Anesthesiology 70: 299-304.
Dyve, SE, Gjedde A, Diksic M, Sherwin A,
Hakim AM (1989) In vivo quantification of blood-brain transfer and
binding of (
I)heat,
an alpha-1 adrenoceptor antagonist. Synapse 3: 205-212.
Waaben J, Husum B, Hansen AJ, Gjedde A (1989) Hypocapnia prevents the decrease in local cerebral metabolism during isoflurane-induced hypotension. J Neurosurg Anesthesiol 1: 29-34.
Hakim AM, Evans AC, Berger L, Kuwabara H, Worsely K, Marchal G, Beil C, Pokrupa R, Diksic M, Meyer E, Gjedde A, Marrett S (1989) The effect of nimodipine on the evolution of human cerebral infarction studied by PET. J Cereb Blood Flow Metab 9: 523-534.
Redies C, Hoffer LJ, Beil C, Marliss EB, Evans AC, Lariviere F, Marrett S, Meyer E, Diksic M, Gjedde A, Hakim AM (1989) Generalized decrease in brain glucose metabolism during fasting in humans studied by pet. Am J Physiol 256: E805-E810.
Gjedde A, Evans AC (1989) PET studies of domoic acid poisoning in humans: Excitotoxic destruction of brain glutamatergic pathways, revealed in measurements of glucose metabolism by positron emission tomography. In: Domoic Acid Toxicity: Canada Diseases Weekly Volume 16S1E, pp.105-109.
Kuwabara H, Evans AC, Gjedde A (1990)
Michaelis-Menten constraints improved cerebral glucose metabolism
and regional lumped constant measurements with
[
F]fluorodeoxyglucose.
J Cereb Blood Flow Metab 10: 180-189.
Gjedde A, Kuwabara H, Hakim A (1990) Reduction of functional capillary density in human brain after stroke. J Cereb Blood Flow Metab 10: 317-316.
Teitelbaum JS, Zatorre RJ, Carpenter S, Gendron D, Evans AC, Gjedde A, Cashman NR (1990) Neurological sequelae of domoic acid intoxication due to ingestion of mussels from Prince Edward Island. N Eng J Med 322: 1781-1787.
Brøndsted HE, Reith J, Gjedde A (1990) Regional glucose phosphorylation rate in brain during acute ethanol intoxication. Acta Neurol Scand 81: 229-231.
Brøndsted HE, and Gjedde A (1990) Phosphorylation rate in rat brain during normoglycemia, hypoglycemia, acute hyperglycemia and in diabetes-prone rats. Acta Neurol Scand 81: 233-236.
Reith J, Dyve S, Kuwabara H, Guttman M, Diksic M,
Gjedde A (1990) Blood-brain transfer and metabolism of
6-[
F]fluoro-l-dopa.
J Cereb Blood Flow Metab 10: 707-719, 1990.
Dyve S, Gjedde A (1991) Glucose metabolism of fetal rat brain in utero, measured with labeled deoxyglucose. Acta Neurol Scand 83: 14-19.
Hogan MJ, Gjedde A, Hakim AM (1991) Activity of the dihydorpyridine calcium channels following cerebral ischemia. Arzneim Forsch/Drug Res 41(I) nr.3a: 332-333.
Kuwabara H, Gjedde A (1991) Measurements of glucose phosphorylation with fdg are not affected by dephosphorylation of fdg-6-phosphate. J Nucl Med 32: 692-698.
Gjedde A, Reith J, Dyve S, Léger G, Guttman M, Diksic M, Evans AC, Kuwabara H (1991) dopa decarboxylase activity of the living human brain. Proc Nat Acad Sci (USA) 88: 2721-2725.
Thompson CJ, Ranger N, Evans AC, Gjedde A (1991) Validation of simultaneous PET emission and transmission scans. J Nucl Med 32: 154-160.
Blomqvist G, Gjedde A, Gutniak M, Grill V, Widen L, Stone-Elander S, Hellstrand E (1991) Facilitated transport of glucose from blood to brain in man and the effect of moderate hypoglycemia on cerebral glucose utilization. Eur J Nucl Med 18: 834-837.
Gjedde A, Dyve S, Yang Y-J, McHugh M,
Pappius M (1991) Bi-Affinity
-1
adrenoceptor binding in normal rat brain in vivo. Synapse
9: 1-6.
Hogan MJ, Gjedde A, Hakim AM (1991) In-vivo binding of nimodipine in brain II. Binding kinetics in focal cerebral ischemia. J Cereb Blood Flow Metab 11: 771-778.
Brust P, Baethmann A, Gjedde A, Ermisch A (1991) Atrial natriuretic peptide augments the blood-brain transfer of water but not leucine and glucose. Brain Res 564: 91-96.
Ohta S, Meyer E, Thompson CJ and Gjedde A (1992) Oxygen consumption of the living human brain measured after a single inhalation of positron emitting oxygen. J Cereb Blood Flow Metab 12: 179-192.
Hogan MJ, Gjedde A, Hakim AM (1992) The in-vivo distribution of CGS-19755 within brain in a model of focal cerebral ischemia. J Neurochem 58: 186-191.
Guttman M, Léger G, Cederbaum JM, Reches A, Woodward W, Evans A, Diksic M, Gjedde A (1992) 3-O-methyldopa administration does not alter fluorodopa transport into the brain. Ann Neurol 31: 638-643.
Brust P, Shaya EK, Jeffries KJ, Dannals RF,
Ravert HT, Wilson AA, Conti PS, Wagner Jr. HN, Gjedde A,
Ermisch A, Wong DF (1992) Effects of vasopressin on blood-brain
transfer of L-[
C]methionine
in dogs. J Neurochem 59: 1421-1429.
Zatorre R, Evans AC, Meyer E, Gjedde A (1992) Lateralization of phonetic and pitch discrimination in speech processing. Science 256: 846-849.
Spencer D, Robbins R, Naftolin F, Marek K, Vollmer T, Leranth C, Roth R, Price L, Gjedde A, Bunney B, Sass K, Elsworth J, Kier E, Makuch R, Hoffer P, Redmond D (1992) Unilateral transplantation of human fetal mesencephalic tissue into the caudate nucleus of patients with Parkinson’s disease. New Engl J Med 327: 1541-1548.
Kuwabara H, Cumming P, Reith J, Léger G, Diksic M, Evans A, Gjedde A (1993) Human striatal L-DOPA decarboxylase activity estimated in vivo using 6-[18F]fluoro-DOPA and positron emission tomography: Error analysis and application to normal subjects. J Cereb Blood Flow Metab 13: 43-56.
Hoshi H, Kuwabara H, Léger G, Cumming P,
Guttman M, Gjedde A (1993) 6-[
F]fluoro-L-DOPA
metabolism in living human brain: A comparison of six analytical
methods. J Cereb Blood Flow Metab 13: 57-69.
Gjedde A, Kuwabara H (1993) Absent recruitment of capillaries in brain tissue recovering from stroke. Acta Neurochir 57: 35-40.
Cumming P, Léger GC, Kuwabara H, Gjedde
A (1993) Pharmacokinetics of plasma
6-[
F]fluoro-L-3,4-dihydroxy-phenylalanine
([
F]FDOPA)
in humans. J Cereb Blood Flow Metab 13: 668-675.
Guttman M, Léger G, Reches A, Evans A, Kuwabara H, Cedarbaum JM, Gjedde A (1993) Administration of the new comt inhibitor OR-611 increases striatal uptake of fluorodopa. Movement Disorders 8: 298-304.
Gjedde A, Léger G, Cumming P, Yasuhara Y, Evans AC, Guttman M, Kuwabara H (1993) Striatal L-DOPA decarboxylase activity in Parkinson’s disease in vivo: Implications for the regulation of dopamine synthesis. J Neurochem 61: 1538- 1541.
Takada A, Grdiša N, Diksic M, Gjedde A, Yamamoto YL (1993) Rapid steady-state analysis of blood-brain transfer of L-tryptophan in rat, with special reference to the plasma protein binding. Neurochem Int 23: 351-359.
Cumming P, Gjedde A (1993) Kinetics of the
uptake of [
H]paroxetine
in the rat brain. Synapse 15: 124-129.
Cumming P, Vincent S, Gjedde A (1994)
Histamine H
binding sites in the rat brain: Localization in the nucleus solitary
tract. Brain Res 641: 198-202.
Cumming P, Gjedde A (1994) Subclasses of
histamine H
binding sites in the rat brain. Brain Res 641: 203-207.
Waaben J, Sørensen HR, Andersen UL, Gefke K, Lund J, Aggestrup S, Laursen H, Gjedde A (1994) Brain damage following low flow cardiopulmonary bypass in pigs. Eur J Cardio-Thoracic Surg 8: 91-96.
Waaben J, Sørensen HR, Andersen UL, Gefke K, Lund J, Aggestrup S, Laursen H, Gjedde A (1994) Arterial line filtration protects brain microcirculation during cardiopulmonary bypass. J Thorac Cardiovasc Surg 107: 1030-1035.
Cumming P, Kuwabara H, Gjedde A (1994)
Kinetic analysis of 6-[
F]fluoro-L-dihydroxyphenyl-alanine
([
F]DOPA)
metabolism in the rat. J Neurochem 63: 1675-1682.
Cumming P, Venkatachalam TK, Rajagopal S, Diksic
M, Gjedde A (1994) Kinetics of the cerebral uptake of
-[
C]methyl-para-tyrosine
in the rat. Synapse 17: 125-128.
Zeitouni AG, Yamamoto YL, Black M, Gjedde A (1994) Functional imaging of head and neck tumors using positron emission tomography. J Otolaryngol 23: 77-80.
Berger R, Gjedde A, Heck J, Müller E, Krieglstein J, Jensen A (1994) Extension of the 2-deoxyglucose method to the fetus in utero: Theory and normal values for the cerebral glucose consumption in fetal guinea pigs. J Neurochem 63: 271-279.
Coghill RC, Talbot JD, Evans AC, Meyer E, Gjedde A, Bushnell MC, Duncan GH (1994) Distributed processing of pain and vibration by the human brain. J Neuroscience 14: 4095-4108.
Cumming P, Laliberté C, Gjedde A
(1994) Distribution of histamine H
binding in forebrain of mouse and guinea pig. Brain Res 664:
276-279.
Reith J, Benkelfat C, Sherwin A, Yasuhara Y, Kuwabara H, Andermann F, Bachneff S, Cumming P, Diksic M, Dyve S, Etienne P, Evans A, Lal S, Shevell M, Savard G, Wong D, Chouinard G, Gjedde A (1994) Elevated dopa decarboxylase activity in living brain of patients with psychosis. Proc Nat Acad Sci USA 91: 11651-11654.
Benkelfat C, Bradwejn J, Meyer E, Ellenbogen M,
Milot S, Gjedde A, Evans A (1995) Functional neuroanatomy of
CCK
-induced
anxiety in normal healthy volunteers. Am J Psychiat 152:
1180-1184.
Cumming P, Ase A, Diksic M, Harrison J, Kuwabara H, Laliberte C, Gjedde A (1995) Metabolism and blood-brain clearance of L-3,4-dihydroxy-[3H]phenylalanine ([3H]DOPA) and 6-[18F]fluoro-L-DOPA in the rat. Biochem Pharmacol 50: 943-946.
Cumming P, Kuwabara H, Ase A, Gjedde A (1995) Regulation of DOPA decarboxylase activity in brain of living rat. J Neurochem 65: 1381-1390.
Dyve S, Yang Y-J, McHugh M, Gjedde A,
Pappius H (1995) Effect of injury on the bi-affinity
-adrenoceptor
binding in the rat brain in vivo. Synapse 19: 88-96
Kuwabara H, Cumming P, Yasuhara Y, Leger G, Guttman M, Diksic M, Evans AC, Gjedde A (1995) Regional striatal DOPA transport and decarboxylation activity in Parkinson’s disease. J Nucl Med 36: 1226-1231.
Wang GJ, Volkow ND, Logan J, Fowler JS, Schlyer D, MacGregor RR. Hitzemann RJ, Gjedde A, Wolf AP (1995) Serotonin 5-HT2 receptor availability in chronic cocaine abusers. Life Sciences 56: PL299-303.
Ohta S, Meyer E, Fujita H, Reutens DC, Evans A, Gjedde A (1996) Cerebral [O-15]water clearance in humans determined by PET. I. Theory and normal values. J Cereb Blood Flow Metab 16: 765-780.
Murase K, Kuwabara H, Yasuhara Y, Evans AC, Gjedde A (1996) Mapping of change in cerebral glucose utilization using fluorine-18 fluorodeoxyglucose double injection and the constrained weighted-integration method. IEEE Transact Med Imag : 824-835.
Reutens DC, McHugh MD, Toussaint PJ, Evans AC, Gjedde A, Meyer E. Stewart DJ (1997) l-Arginine infusion increases basal but not activated cerebral blood flow in humans. J Cereb Blood Flow Metab 17: 309-315
Gee AD, Smith DF, Gjedde A (1995) The
synthesis of [O-methyl-
]venlafaxine:
A potential tracer of the 5-HT reuptake site. J Labelled Comp
Radiopharm 37: 309-310.
Wong DF, Harris JC, Naidu S, Yokoi F, Marenco S, Dannals RF, Ravert HT, Yaster M, Evans A, Rousset O, Bryan RN, Gjedde A, Kuhar MJ, Breese GR (1996) Dopamine transporters are markedly reduced in Lesch-Nyhan Disease in vivo. Proc NatAcad Sci USA 93: 5539-5543.
Berger R, Gjedde A, Rischke R, Muller E, Heck J, Krieglstein J, Jensen A (1996) Local cerebral glucose utilization in fetal guinea pigs at 0.75 gestation. Eur J Obstet Gynecol Reprod Biol 66: 175-178.
Møller N, Frystyk J, Skjærbæk C, Pedersen HB, Christensen C, Schmitz O, Gee A, Gjedde A, Zapf J, Ørskov H (1996) Systemic and regional tumour metabolism in a patient with non-islet cell tumour hypoglycemia - role of increased levels of free insulin-like growth factors. Diabetologia 39: 1534-1535.
Bøtker HE, Böttcher M, Schmitz O, Gee A, Hansen SB, Cold GE, Nielsen TT, Gjedde A (1997) Glucose uptake and lumped constant variability in normal human hearts determined with [F-18]fluorodeoxyglucose. J Nucl Cardiol 4: 125-132
Wong DF, Young D, Wilson PD, Meltzer CC, Gjedde A (1997) Quantification of neuroreceptors in the living human brain .3. D-2-like dopamine receptors - theory, validation, and changes during normal aging. J Cereb Blood Flow Metab 17: 316-330
Wong DF, Pearlson GD, Tune LE, Young LT, Meltzer CC, Dannals RF. Ravert HT, Reith J, Kuhar MJ, Gjedde A (1997) Quantification of neuroreceptors in the living human brain .4. effect of aging and elevations of D-2-like receptors in schizophrenia and bipolar illness. J Cereb Blood Flow Metab 17: 331-342
Berger R, Gjedde A, Hargarter L, Hargarter S, Krieglstein J, Jensen A (1997) Regional cerebral glucose utilization in immature fetal guinea pigs during maternal isocapnic hypoxemia. Pediat Res 42: 311-316
Wong DF, Singer HS, Brandt J, Shaya E, Chen C, Brown J, Kimball AW. Gjedde A, Dannals RF, Ravert HT, Wilson PD, Wagner HN (1997) D2-like dopamine receptor density in tourette syndrome measured by pet. J Nucl Med 38: 1243-1247
Smith DF, Jensen PN, Gee AD, Hansen SB, Danielsen E, Andersen F. Saiz PA, Gjedde A (1997) PET neuroimaging with [C-11]venlafaxine - serotonin uptake inhibition, biodistribution and binding in living pig brain. Eur Neuropsychopharmacol 7:195-200
Johannsen P, Jakobsen JK, Gjedde A, Christensen T Gulmann NC, Abelskov KE, Ehlers L (1997) [A clinic for the study of dementia — 110 consecutive patients] Ugeskr Laeger 159: 1246-1251
Cumming P, Ase A, Laliberte C, Kuwabara H, Gjedde A (1997) In vivo regulation of DOPA decarboxylase by dopamine receptors in rat brain. J Cereb Blood Flow Metab 17: 1254-1260.
Johannsen P. Jakobsen J. Bruhn P. Hansen SB. Gee A. Stodkilde-Jorgensen H. Gjedde A. (1997) Cortical sites of sustained and divided attention in normal elderly humans Neuroimage. 6: 145-155.
Deep P. Gjedde A. Cumming P. (1997) On the accuracy of an [f-18]fdopa compartmental model - evidence for vesicular storage of [f-18]fluorodopamine in vivo J Neurosci Meth 76: 157-165
Deep P. Kuwabara H. Gjedde A. Cumming P. (1997) The kinetic behaviour of [H-3]dopa in living rat brain investigated by compartmental modelling of static autoradiograms. J Neurosci Meth 78: 157-168
Gee AD. Moldt P. Gjedde A. (1997) The labelling of a novel tropane derivative [C-11]NS 2214 (BMS-204756) - an inhibitor of the dopamine transporter. J Label Comp & Radiopharm 39: 959-972
Poulsen PH. Smith DF. Ostergaard L. Danielsen EH. Gee A. Hansen SB. Astrup J. Gjedde A (1997) In vivo estimation of cerebral blood flow, oxygen consumption and glucose metabolism in the pig by [o-15]water injection, [o-15]oxygen inhalation and dual injections of [F-18]fluorodeoxyglucose. J Neurosci Meth 77: 199-209
Reutens DC, Gjedde A, Meyer E (1998) Regional lumped constant differences and asymmetry in fluorine-18-FDG-uptake in temporal lobe epilepsy.J Nucl Med 39: 176-180.
Cumming P, Gjedde A (1998) Compartmental analysis of dopa decarboxylation in living brain from dynamic positron emission tomograms. Synapse (New York) 29: 37-61.
Ostergaard L, Smith DF, Vestergaard-Poulsen P, Hansen SB, Gee AD, Gjedde A, Gyldensted C (1998) Absolute cerebral blood flow and blood volume measured by magnetic resonance imaging bolus tracking: comparison with positron emission tomography values. J Cereb Blood Flow Metab 18: 425-432
Reith J, Cumming P, Gjedde A (1998) Enhanced [3H]DOPA and [3H]dopamine turnover in striatum and frontal cortex in vivo linked to glutamate receptor antagonism. J Neurochem 70: 1979-1985
Cumming P, Ase A, Kuwabara H, Gjedde A, (1998) [H-3]Dopa formed from [h-3]tyrosine in living rat brain is not committed to dopamine synthesis, J Cereb Blood Flow Metab 18: 491-499
Pedersen JR, Johannsen P, Bak CK, Kofoed B, Saermark K, Gjedde A (1998) Origin of Human Motor Readiness Field Linked to Left Middle Frontal Gyrus by MEG and PET. Neuroimage 8: 214-220
Ostergaard L, Johannsen P, Host-Poulsen P Vestergaard-Poulsen P; Asboe H, Gee AD, Hansen SB, Cold GE, Gjedde A, Gyldensted C. (1998) Cerebral blood flow measurements by magnetic resonance imaging bolus tracking: comparison with [(15)O]H2O positron emission tomography in humans. J Cereb Blood Flow Metab 18: 935-940
Léger G, Gjedde A, Kuwabara H, Guttman M, Cumming P (1998) Effect of catechol-O-methyltransferase inhibition on brain uptake of [18F]fluorodopa: Implications for compartmental modelling and clinical usefulness. Synapse 30: 351-361.
Svensson P, Johannsen P, Jensen TS, Arendt-Nielsen L, Nielsen J, Stødkilde-Jørgensen H, Gee AD, Hansen SB, Gjedde A (1998) Cerebral blood flow changes evoked by two levels of painful tonic and phasic heat stimulation: A positron emission tomography study. Eur J Pain 2: 95-107
Vafaee M, Meyer E, Marrett S, Evans AC, Gjedde A (1998) Increased oxygen consumption in human visual cortex: Response to visual stimulation. Acta Neurol Scand 98: 85-89.
Ptito M, Johannsen P, Faubert J, Gjedde A (1999) Activation of human extrageniculostriate pathways after damage to area V1.Neuroimage 9: 97-107
Ohta S, Reutens DC, Gjedde A (1999) Brief vibrotactile stimulation does not increase cortical oxygen consumption when measured by single inhalation of positron emitting oxygen. J Cereb Blood Flow Metab 19: 260-265
Fujita H, Kuwabara H, Reutens DC, Gjedde A (1999) Oxygen consumption of cerebral cortex fails to increase during continued vibrotactile stimulation. J Cereb Blood Flow Metab 19: 266-271
Vafaee MS, Meyer E, Marrett S, Paus T, Evans AC, Gjedde A. (1999) Frequency-dependent changes in cerebral metabolic rate of oxygen during activation of human visual cortex. J Cereb Blood Flow Metab 19: 272-277
Ptito M, Dalby M, Gjedde A. (1999) Visual field recovery in a patient with bilateral occipital lobe damage. Acta Neurol Scand 99: 252-254
Cumming P, Reith J, Gjedde A (1999) Cocaine withdrawal and the cerebral influx of [18F]fluoro-L-DOPA (FDOPA). Neuropsychopharmacology 20: 395-398
Smith DF, Gee AD, Hansen SB, Moldt P, Nielsen EO, Scheel-Kruger J, Gjedde A (1999) Uptake and distribution of a new SSRI, NS2381, studied by PET in living porcine brain. Eur Neuropsychopharmacol 9: 351-359
Danielsen EH, Smith DF, Gee AD, Venkatachalam TK
Hansen SB, Hermansen F, Gjedde A, Cumming P (1999) Cerebral
6-[
F]fluoro-L-DOPA
(FDOPA) metabolism in pig studied by positron emission tomography.
Synapse 33: 247-258
Borbely K, Brooks RA, Wong DF, Burns RS, Cumming P, Gjedde A, Di Chiro G (1999) NMSP binding to dopamine and serotonin receptors in MPTP-induced parkinsonism: relation to dopa therapy. Acta Neurol Scand 100: 42-52
Bøtker HE, Goodwin GW, Holden JE, Doenst T, Gjedde A, Taegtmeyer H (1999) Myocardial glucose uptake measured with fluorodeoxyglucose: a proposed method to account for variable lumped constants. J Nucl Med 40: 1186-1196
Mirz F, Pedersen CB, Ishizu K, Johannsen P, Ovesen T, Stødkilde-Jørgensen H, Gjedde A (1999) Positron emission tomography of cortical centers of tinnitus. Hear Res 134: 133-144.
Wiggers H, Böttcher M, Nielsen TT, Gjedde A, Bøtker HE (1999) Measurement of myocardial glucose uptake in patients with ischemic cardiomyopathy: application of a new quantitative method using regional tracer kinetic information. J Nucl Med 40: 1292-300
Johannsen P, Jakobsen J, Bruhn P, Gjedde A (1999) Cortical responsesto sustained and divided attention in Alzheimer’s disease. Neuroimage 10: 269-281
Mirz F, Ovesen T, Ishizu K, Johannsen P, Madsen S, Gjedde A, Pedersen CB (1999) Stimulus-dependent central processing of auditory stimuli: a PET study. Scand Audiol 28: 161-169.
Cumming P, Yokoi F, Chen A, Deep P, Dagher A, Reutens D, Kapczinski F, Wong DF, Gjedde A (1999) Pharmacokinetics of radiotracers in human plasma during positron emission tomography. Synapse 34: 124-134
Deep P, Dagher A, Sadikot A, Gjedde A, Cumming P (1999) Stimulation of dopa decarboxylase activity in striatum of healthy human brain secondary to NMDA receptor antagonism with a low dose of amantadine. Synapse 34: 313-318
Mirz F, Gjedde A, Stødkilde-Jørgensen H, Pedersen CB (2000) Functional brain imaging of tinnitus-like perception induced by aversive auditory stimuli. NeuroReport 11: 633-637
Vafaee MS, Gjedde A (2000) Model of blood-brain transfer of oxygen explains non-linear flow-metabolism coupling during stimulation of visual cortex. J Cereb Blood Flow Metab 20: 747-754.
Pedersen CB, Mirz F, Ovesen T, Ishizu K, Johannsen P, Madsen S, Gjedde A (2000) Cortical centres underlying auditory temporal processing in humans: a PET study. Audiology 39: 30-37.
Danielsen EH, Cumming P, Andersen F, Bender D, Brevig T, Falborg L, Gee A, Gillings NM, Hansen SB, Hermansen F, Johansen J, Johansen TE, Dahl-Jørgensen A, Jørgensen HA, Meyer M, Munk O, Pedersen EB, Poulsen PH, Rodell AB, Sakoh M, Simonsen CZ, Smith DF, Sørensen JC, Østergard L, Zimmer J, Gjedde A(2000) The DaNeX study of embryonic mesencephalic, dopaminergic tissue grafted to a minipig model of Parkinson’s disease: Preliminary findings of effect of MPTP poisoning on striatal dopaminergic markers. Cell Transplant 9: 247-259.
Bøtker HE, Wiggers H, Bøttcher M, Christiansen JS, Nielsen TT, Gjedde A, Schmitz O (2000) Short-term effects of growth hormone on myocardial glucose uptake in healthy humans. Am J Physiol (Endocrinol Metab) 278: E1053-E1059.
Rousset OG, Deep P, Kuwabara H, Evans AC, Gjedde A, Cumming P (2000) Effect of partial volume correction on estimates of the influx and cerebral metabolism of 6-[(18)F]fluoro-L-dopa studied with PET in normal control and Parkinson’s disease subjects. Synapse 37: 81-89.
Kupers RC, Gybels JM, Gjedde A (2000) Positron emission tomography study of a chronic pain patient successfully treated with somatosensory thalamic stimulation. Pain 87: 295-302.
Ishizu K, Smith DF, Bender D, Danielsen E, Hansen SB, Wong DF, Cumming P, Gjedde A (2000) Positron emission tomography of radioligand binding in porcine striatum in vivo: Haloperidol inhibition linked to endogenous ligand release. Synapse38: 87-101.
Sakoh M, Rohl L, Gyldensted C, Gjedde A, Ostergaard L (2000) Cerebral blood flow and blood volume measured by magnetic resonance imaging bolus tracking after acute stroke in pigs: comparison with [(15)O]H(2)O positron emission tomography. Stroke 31: 1958-1964.
Mirz F, Gjedde A, Ishizu K, Pedersen CB (2000) Cortical networks subserving the perception of tinnitus–a PET study. Acta Otolaryngol Suppl. 543: 241-243.
Johannsen P, Jakobsen J, Gjedde A (2000) Statistical maps of cerebral blood flow deficits in Alzheimer’s disease. Eur J Neurol 7: 385-392.
Vafaee MS, Meyer E, Gjedde A (2000) Impaired activation of oxygen consumption and blood flow in visual cortex of patients with mitochondrial encephalomyopathy. Ann Neurol 48: 676-679.
Sakoh M, Ostergaard L, Rohl L, Smith DF, Simonsen CZ, Sorensen JC, Poulsen PV, Gyldensted C, Sakaki S, Gjedde A (2000) Relationship between residual cerebral blood flow and oxygen metabolism as predictive of ischemic tissue viability: sequential multitracer positron emission tomography scanning of middle cerebral artery occlusion during the critical first 6 hours after stroke in pigs. J Neurosurg 93: 647-657.
Danielsen EH, Smith D, Hermansen F, Gjedde A, Cumming P (2001) Acute neuroleptic stimulates DOPA decarboxylase in porcine brain in vivo. Synapse 41: 172-175
Cumming P, Danielsen EH, Vafaee M, Falborg L, Steffensen E, Sorensen JC, Gillings N, Bender D, Marthi K, Andersen F, Munk O, Smith D, Moller A, Gjedde A (2001) Normalization of markers for dopamine innervation in striatum of MPTP-lesioned miniature pigs with intrastriatal grafts. Acta Neurol Scand 103: 309-315
Smith DF, Bender D, Marthi K, Cumming P, Hansen SB, Peters D, Ostergaard Nielsen E, Scheel-Kruger J, Gjedde A (2001) Synthesis and evaluation of racemic.... Nucl Med Biol 28: 265-270
Gjedde A, Wong DF (2001) Quantification of neuroreceptors in living human brain. V. Endogenous neurotransmitter inhibition of haloperidol binding in psychosis. J Cereb Blood Flow Metab 21: 982-994.
Smith DF, Hansen SB, Ostergaard L, Gee AD, Danielsen E, Ishizu K, Bender D, Poulsen PH, Gjedde A (2001) [14C]Serotonin uptake and [O-methyl-11C]venlafaxine kinetics in porcine brain. Nucl Med Biol 28: 633-638.
Sakoh M, Ostergaard L, Gjedde A, Rohl L, Vestergaard-Poulsen P, Smith DF, Le Bihan D, Sakaki S, Gyldensted C (2001) Prediction of tissue survival after middle cerebral artery occlusion based on changes in the apparent diffusion of water. J Neurosurg 95: 450-458.
Danielsen EH, Smith DF, Andersen F, Gee AD, Bender D, Hansen SB, Hermansen F, Ostergaard L, Cumming P, Gjedde A (2001) FDOPA metabolism in the adult porcine brain: influence of tracer circulation time and VOI selection on estimates of striatalDOPA decarboxylation. J Neurosci Methods 111: 157-168.
Videbech P, Ravnkilde B, Pedersen AR, Egander A, Landbo B, Rasmussen NA, Andersen F, Stodkilde-Jorgensen H, Gjedde A, Rosenberg R (2001) The Danish PET/depression project: PET findings in patients with major depression. Psychol Med 31: 1147-1158.
Watanabe H, Andersen F, Simonsen CZ, Evans SM, Gjedde A, Cumming P (2001) MR-based statistical atlas of the Gottingen minipig brain. Neuroimage 14: 1089-1096.
Ptito M, Kupers R, Faubert J, Gjedde A (2001) Cortical representation of inward and outward radial motion in man. Neuroimage 14: 1409-1415.
Witting N, Kupers RC, Svensson P, Arendt-Nielsen L, Gjedde A, Jensen TS (2001) Experimental brush-evoked allodynia activates posterior parietal cortex. Neurology 57: 1817-1824.
Gjedde A, Marrett S (2001) Glycolysis in neurons, not astrocytes, delays oxidative metabolism of human visual cortex during sustained checkerboard stimulation in vivo. J Cereb Blood Flow Metab 21: 1384-1392.
Marthi K, Bender D, Gjedde A, Smith DF
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C]Mirtazapine
for PET neuroimaging: Radiosynthesis and initial evaluation in the
living porcine brain. Eur Neuropsychopharmacol 12: 427-432.
Ravnkilde B, Videbech P, Rosenberg R, Gjedde A, Gade A (2002) Putative tests of frontal lobe function: A PET-study of brain activation during Stroop’s test and Verbal Fluency. J Clin Exp Neuropsychol 24: 534-547.
Videbech P, Ravnkilde B, Pedersen TH, Hartvig H, Egander A, Clemmensen K, Rasmussen NA, Andersen F, Gjedde A, Rosenberg R (2002) The Danish PET/depression project: clinical symptoms and cerebral blood flow. A regions-of-interest analysis. Acta Psychiatr Scand 106: 35-44.
Cumming P, Wong DF, Gillings N, Hilton J, Scheffel U, Gjedde A(2002) Specific binding of [11C]raclopride and N-[(3)H]propyl-norapomorphine to dopamine receptors in living mouse striatum: occupancy by endogenous dopamine and guanosine triphosphate-free G protein. J Cereb Blood Flow Metab 22: 596-604.
Gjedde A (2002) Cerebral blood flow change in arterial hypoxemia is consistent with negligible oxygen tension in brain mitochondria. Neuroimage 17: 1876-1881.
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Moller A, Zimmer J, Gjedde A, Cumming P (2002) Quantitative
[
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Geday J, Gjedde A, Boldsen AS, Kupers R (2003) Emotional valence modulates activity in the posterior fusiform gyrus and inferior medial prefrontal cortex in social perception. Neuroimage 18: 675-684.
Gründer G, Vernaleken I, Muller MJ, Davids E, Heydari N, Buchholz HG, Bartenstein P, Munk OL, Stoeter P, Wong DF, Gjedde A, Cumming P (2003). Subchronic haloperidol downregulates dopamine synthesis capacity in the brain of schizophrenic patients in vivo. Neuropsychopharmacology 28: 787-794.
Videbech P, Ravnkilde B, Kristensen S, Egander A, Clemmensen K, Rasmussen NA, Gjedde A, Rosenberg R (2003) The Danish PET/depression project: poor verbal fluency performance despite normal prefrontal activation in patients with major depression. Psychiatry Res 123: 49-63.
Ptito M, Faubert J, Gjedde A, Kupers R (2003) Separate neural pathways for contour and biological-motion cues in motion-defined animal shapes. Neuroimage 19: 246-252.
Fortin A, Faubert J, Ptito A, Gjedde A, Kupers R, Ptito M (2003) Stereoscopic processing in the human brain as a function of binocular luminance rivalry. Neuroreport 14: 1163-1166.
Cumming P, Gillings NM, Jensen SB, Bjarkam C, Gjedde A (2003) Kinetics of the uptake and distribution of the dopamine D(2,3) agonist (R)-N-[1-(11)C]n-propylnorapomorphine in brain of healthy and MPTP-treated Göttingen miniature pigs. Nucl Med Biol 30: 547-553.
Cumming P, Rosa-Neto P, Watanabe H, Smith D, Bender D, Clarke PB, Gjedde A (2003) Effects of acute nicotine on hemodynamics and binding of [11C]raclopride to dopamine D2,3 receptors in pig brain. Neuroimage 19: 1127-1136.
Sakoh M, Gjedde A (2003). Neuroprotection in hypothermia linked to redistribution of oxygen in brain. Am J Physiol 285: H17-H25.
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Arnfred SM, Lind NM, Moustgaard A, Hansen AK, Gjedde A (2003) Minipig negative slow wave demonstrates target/nontarget differences in P300 paradigm. Neuroimage 20: 587-590.
Borbely K, Gjedde A, Nyary I, Czirjak S, Donauer N, Buck A (2003) Speech activation of language dominant hemisphere: a single-photon emission computed tomography study. Neuroimage 20: 987—994.
Vafaee MS, Gjedde A (2004) Spatially dissociated flow-metabolism coupling in brain activation. Neuroimage 21: 507-515.
Vafaee MS, Østergaard K, Sunde N, Gjedde A, Dupont E, Cumming P (2004) Focal changes of oxygen consumption in cerebral cortex of patients with Parkinson’s disease during subthalamic stimulation. Neuroimage 22: 966-974.
Arnfred SM, Lind NM, Gjedde A, Hansen AK (2004) Scalp recordings of mid-latency AEP and auditory gating in the Gottingen minipig: a new animal model in information processing research. Int J Psychophysiol 52: 267-275.
Videbech P, Ravnkilde B, Gammelgaard L, Egander A, Clemmensen K, Rasmussen NA, Gjedde A, Rosenberg R (2004) The Danish PET/depression project: performance on Stroop’s test linked to white matter lesions in the brain. Psychiatry Res 130: 117-130.
Lou HC, Rosa P, Pryds O, Karrebaek H, Lunding J, Cumming P, Gjedde A (2004) ADHD: Increased dopamine receptor availability linked to attention deficit and low neonatal cerebral blood flow. Dev Med Child Neurol 46: 179-183.
Rosa-Neto P, Gjedde A, Olsen AK, Jensen SB, Munk OL, Watanabe H, Cumming P (2004) MDMA-evoked changes in [(11)C]raclopride and [(11)C]NMSP binding in living pig brain. Synapse 53: 222-233.
Rosa-Neto P, Olsen AK, Gjedde A, Watanabe H, Cumming P (2004) MDMA-evoked changes in cerebral blood flow in living porcine brain: Correlation with hyperthermia. Synapse 53: 214-221.
Kumakura Y, Danielsen EH, Reilhac A, Gjedde A, Cumming P (2004) Levodopa effect on [18F]fluorodopa influx to brain: normal volunteers and patients with Parkinson’s disease. Acta Neurol Scand 110: 188-195.
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Kupers RC, Fortin A, Astrup J, Gjedde A, Ptito M (2004) Recovery of anterograde amnesia in a case of craniopharyngioma. Arch Neurol 61: 1948-1952
Vuust P, Pallesen KP, Bailey C, van Zuijen TL, Gjedde A, Roepstorff A, Østergaard L (2004) To musicians, the message is in the meter. Pre-attentive neuronal responses to incongruent rhythm are left-lateralized in musicians. Neuroimage 24: 560-564.
Gjedde A, Johannsen P, Cold GE, Østergaard L (2005) Cerebral metabolic response to low blood flow: Possible role of cytochrome oxidase inhibition. J Cereb Blood Flow Metab 25: 1183-1196.
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Rosa-Neto P, Lou HC, Cumming P, Pryds O, Karrebaek H, Lunding J, Gjedde A (2005) Methylphenidate-evoked changes in striatal dopamine correlate with inattention and impulsivity in adolescents with attention deficit. Neuroimage 25: 868-876.
Kumakura Y, Vernaleken I, Gründer G, Bartenstein P, Gjedde A, Cumming P (2005) PET studies of net blood-brain clearance of FDOPA to human brain: Age-dependent decline of [18F]fluorodopamine storage capacity. J Cereb Blood Flow Metab 25: 807-819.
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Gjedde A (1991) Kinetic analysis of radioligand binding in brain in vivo. In: Radiopharmaceuticals and Brain Pathology Studied with PET and SPECT. Diksic M and Reba RC, eds, CRC Press, Boca Raton, pp. 337-355.
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(1992) Effect of injury on
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Wong DF, Ricaurte G, Grunder G, Rothman R, Naidu S, Singer H, Harris J, Yokoi F, Villemagne V, Szymanski S, Gjedde A, Kuhar M. (1998) Dopamine transporter changes in neuropsychiatric disorders. Adv Pharmacol 42: 219-223.
Gjedde A (2002a) Coupling of blood flow to neuronal excitability. In: The Neuronal Environment: Brain Homeostasis in Health and Disease. Ed. Walz W, Humana Press Inc., Totowa, N.J., pp. 233-257.
Gjedde A (2002b) Coupling and compartmentation of cerebral blood flow and metabolism. In: Cerebral Blood Flow. Mechanisms of Ischemia, Diagnosis and Therapy. Ed. Pinsky M, Springer-Verlag, Berlin-Heidelberg, pp. 72-95.
Gjedde A (2002c) Selvet i neurobiologisk betydning. I: Vinkler på Selvet - en antologi om selvbegrebets anvendelse i psykologien. Bertelsen P, Hermansen M, Tønnesvang J (red.), Klim, Århus, pp. 343-362.
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Gjedde A, Vafaee MS, Østergaard L (2003) PET og hjernearbejde. Energiforsyning og stofomsætning i hjernen. In: På sporet af det indre liv. PET i Århus 1993-2003, Rodell AB (ed.). Professionelle og Eksperimenterende Tekster, Århus, pp. 137-149.
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Gjedde A, Hansen AJ, Siemkowicz E (1980) Rapid simultaneous determination of regional cerebral blood flow and blood-brain glucose transfer in rats. In: Cerebral Metabolism and Neural Function (eds. Passoneau J et al.), Baltimore: Williams & Wilkins, pp. 151-160.
Gjedde A (1981) Regulation and adaptation of substrate transport to the rat brain. In: Advances in Physiological Sciences, Volume 7, Pergamon Press, Oxford, pp. 307-315.
Lauritzen M, Gjedde A, Hansen AJ (1982) Associations between spreading depression and migraine. In: Advances in Migraine Research and Therapy (ed. Rose FC), Raven Press, New York, pp. 121-125.
Gjedde A, Diemer NH (1985) Relationship between unidirectional and net uptake of glucose and glucose analogs into brain: On the variability of transfer and lumped constants. In: The Metabolism of the Human Brain Studied with Positron Emission Tomography (Greitz T et al., eds), Raven Press, New York, pp. 207-214.
Gjedde A, Heiss W-D, Wienhard K (1985)
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Gjedde A, Fuglsang A (1985) Blood-brain barrier transfer of glucose analogs in newborn rats. In: Carrier-Mediated Transport of Solutes from Blood to Tissue (Yudelivich DL, Mann GE, eds.), Pitman, London, pp. 275-281.
Gjedde A, Wong DF, Wagner HNJr: (1986) Transient analysis of irreversible and reversible tracer binding in human brain in vivo. In: PET and NMR: New Perspectives in Neuroimaging and Clinical Neurochemistry (Battistin L, ed.), Alan R Liss, New York, pp. 223-235.
Nedergaard M, Gjedde A, Diemer NH (1986) The effects of hyperglycemia in experimental stroke. In: Acute Brain Ischemia. Medical and Surgical Therapy (Battistini N, Fiorani P, Courbier R, Plum F, eds.), Serono Symposia Publications, volume 32, Raven Press, New York, pp. 47-52.
Wienhard K, Gjedde A, Heiss W-D, Herholz K, Pawlik G (1987) Improved measurement of regional glucose metabolism by individual determination of the lumped and kinetic constants in stroke patients. In: Cerebral Ischemia and Hemorheology (Hartmann A, Kuschinsky W, eds.), Springer Verlag, Berlin-Heidelberg, pp. 186-201.
Gjedde A (1987) Interpretation of tracer uptake in brain tumors. Clinical Efficacy of Positron Emission Tomography (eds. Heiss WD, Pawlik G, Herholz K, Wienhard K). Martinus Nijhoff, Dordrecht, pp. 401-412.
Wong DF, Broussolle EP, Wand G, Villemagne V, Dannals RF, Links JM, Zacur HA, Harris J, Naidu S, Braestrup C, Wagner HNJr, Gjedde A (1988) In vivo measurement of dopamine receptors in human brain by positron emission tomography. Age and sex differences. Central Determinants of Age-Related Declines in Motor Function (Joseph JA, ed.), Annals of the New Academy of Sciences, Volume 515, New York, pp. 203-214.
Gjedde A (1988) Examination of organ physiology by positron emission tomography. The Biophysics of Organ Cryopreservation (Pegg DE, Karow AM, Jr, eds.). Plenum Press, New York, pp. 461-476.
Gjedde A, Beil C, Meyer E, Evans AC, Hakim AM (1988) Density of capillaries in regions of the living human brain affected by stroke. Cerebral Hyperemia and Ischemia (Tomita M, Sawada T, Naritomi H, Heiss WD, eds.). Excerpta Medica, Amsterdam, pp. 91-102.
Gjedde A (1988) Exchange diffusion of large neutral amino acids between blood and brain. Peptide and Amino Acid Transport Mechanisms in the Central Nervous System (Rakic L, Begley DJ, Davson H, Zlokovic BV, eds.), Stockton Press, New York, pp. 209-217.
Hakim AM, Berger L, Popow D, Gjedde A (1989) Nimodipine binding in cerebral ischemia. Cerebral Ischemia and Calcium (Hartmann A, Kuschinsky W, eds.), Springer Verlag, Berlin-Heidelberg, pp. 206-209.
Gjedde A, Kuwabara H, Berger L, Beil C, Evans AC, Hakim AM (1989) Density of functioning cerebral capillaries in stroke patients, determined by PET. Cerebral Ischemia and Calcium (Hartmann A, Kuschinsky W, eds.), Springer Verlag, Berlin-Heidelberg, pp. 337-349.
Gjedde A (1990) Modeling the dopamine system in vivo. In: In vivo imaging of neurotransmitter functions in brain, heart and tumors, ed. David E. Kuhl, Frontiers in Nuclear Medicine, American College of Nuclear Physicians, U.S. Department of Energy, Washington, D.C., pp. 157-169.
Gjedde A, Ohta S, Kuwabara H, Meyer E (1991) Is oxygen diffusion limiting for blood-brain transfer of oxygen? in: Brain Work and Mental Activity, Alfred Benzon Symposium 31, eds. Lassen NA, Ingvar DH, Raichle ME, Friberg L. Munksgaard, Copenhagen, pp. 177-184.
Ribeiro L, Kuwabara H, Meyer E, Fujita H, Marrett S, Evans AC, Gjedde A (1993) Cerebral blood flow and metabolism during nonspecific bilateral visual stimulation in normal subjects. In: Uemura K, Lassen NA, Jones T, Kanno I, eds. Quantification of Brain Function: Tracer Kinetics and Image Analysis in Brain PET. Amsterdam: Elsevier, 229-234
Gjedde A (1993) The energy cost of neuronal depolarization. In: Functional Organization of the Human Visual Cortex, eds. Gulyas B, Ottoson D, Roland PE, Pergamon Press, Oxford, pp. 291-306.
Kuwabara H, Fujita H, Vafaee MS, Yasuhara Y, Gjedde A, Meyer E (1993) Measurements of tracer arrival delay and dispersion usmg positron emission tomography and tracer [15O]carbonmonoxide Quantification of Brain Function. In Tracer Kinetics and Image Analysis in Brain PET, Uemura K et al., editors. Amsterdam: Elsevier Science Publishers B.V., pp.
Rousset OG, Ma Y, Leger GC, Gjedde A, Evans AC (1993) Correction for partial volume effects in PET using MRI-based simulations of individual human brain metabolism. In Tracer Kinetics and Image Analysis in Brain PET, Uemura K et al., editors. Amsterdam: Elsevier Science Publishers B.V., pp. 113
Gjedde A (1993) Interpreting physiology maps of the living human brain. In Tracer Kinetics and Image Analysis in Brain PET, Uemura K et al., editors. Amsterdam: Elsevier Science Publishers B.V., pp.
Marrett S, Fujita H, Meyer E, Ribeiro L, Evans AC, Kuwabara H, Gjedde A (1993) Stimulus specific increase of oxidative metabolism in human visual cortex. In Tracer Kinetics and Image Analysis in Brain PET, Uemura K et al., editors. Amsterdam: Elsevier Science Publishers B.V., pp.
L. Ribeiro, H. Kuwabara, E. Meyer, H. Fujita, S. Marrett, Evans AC, Gjedde A (1993) Cerebral blood flow and metabolism during nonspecific bilateral visual stimulation in normal subjects. In Tracer Kinetics and Image Analysis in Brain PET, Uemura K et al., editors. Amsterdam: Elsevier Science Publishers B.V., pp.
G.C. Leger, H. Kuwabara, Gjedde A (1993) Parametric DOPA-decarboxylase imaging in vivo: method and errof analysis. In Tracer Kinetics and Image Analysis in Brain PET, Uemura K et al., editors. Amsterdam: Elsevier Science Publishers B.V.,pp. 269-
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Gjedde A (1996) PET criteria of cerebral tissue viability in ischemia. Acta Neurol Scand : 3-5.
Gjedde A (1996) DOPA decarboxylase. Mov Disord 11: 462-463.
Cumming P, Deep P, Rousset O, Evans A, Gjedde A (1997) On the rate of decarboxylation of dopa to dopamine in living mammalian brain. In: Frontiers of Neurology: A Symposium in Honor of Fred Plum. Ann N Y Acad Sci 835: 274-308.
Marrett S, Gjedde A (1997) Changes of blood flow and oxygen consumption in visual cortex of living humans. Adv Exp Med Biol 413: 205-208
Gjedde A, Poulsen PH, Østergaard L (1999) On the oxygenation of hemoglobin in the human brain. Adv Exp Med Biol 471: 67-81
Danielsen E, Smith DF, Poulsen PH, Østergaard L, Gee A, Ishizu K, Venkatachalam TK, Bender D, Hansen S, Gjedde A, Scheel-Krüger J, Møller A (1998) Positron emission tomography of living brain in minipigs and domestic pigs. Scand J Lab Sci Suppl 1: 25: 127-135.
Bass L, Gjedde A, Ott P (1999) Plasma-exchange of protein-bound ligands: Can flux ratios diagnose facilitation? In: Brain Barrier Systems, Alfred Benzon Symposium 45, eds. Paulson OB, Knudsen GM, Moos T. Munksgaard, Copenhagen, pp. 461-472.
Gjedde A, Gee AD, Smith DF (2000) Basic CNS drug transport and binding kinetics in vivo. In: The Blood-Brain Barrier and Drug Delivery to the CNS, Begley DJ, Bradbury MW, Kreuter J (eds), Marcel Dekker, New York, pp. 225-242.
Smith DF, Gee A, Hansen SB, Moldt P, Nielsen EØ, Scheel-Krüger, Ishizu K, Sakoh M, Østergaard L, Poulsen PH, Bender D, Gjedde A (2000) Serotonin release and reuptake studied by PET neuroimaging using fenfluramine, water, oxygen, fluorodeoxyglucose, NS2381, and its enantiomers in living porcine brain. In: Physiological Imaging of the Brain with PET. (Gjedde A, Hansen SB, Knudsen GM, Paulson OB, eds.) Academic Press, San Diego, pp. 237-247.
Wong DF, Nestadt G, Cumming P, Yokoi F, Gjedde A (2000) Partition volume and regional binding potentials of serotonin receptor and transporter ligands. In: Physiological Imaging of the Brain with PET. (Gjedde A, Hansen SB, Knudsen GM, Paulson OB, eds.) Academic Press, San Diego, pp. 257-263.
Bergholt B, Østergaard L, von Oettingen G, Johannsen P, Poulsen PH, Bundgaard H, Asboe H, Cold GE, Gjedde A, Gyldensted C, Astrup J (2000) Cerebral blood flow in volunteers measured by PET and Xe CT/CBF. A comparison. Keio J Med. 49: Suppl 1: A55-A57.
Sakoh M, Østergaard L, Gjedde A (2001) Comparison of multitracer PET and functional MRI in a pig MCAOmodel for acute ischemic stroke. In: Ischemic Blood Flow in the Brain, Fukuuchi Y, Tomita M, Koto A (eds.), Springer Verlag, Tokyo, pp. 226-231.
Gjedde A (2001b) Coupling and compartmentation of cerebral blood flow and metabolism. In: Neuroenergetics: Relevance for Functional Brain Imaging. Eds. Frackowiak RSJ, Magistretti PJ, Shulman RG, Altman JS, Adams M. HFSP, Strasbourg, pp. 160-168.
Gjedde A, Marrett S, Sakoh M, Vafaee M (2002) Model of oxygen delivery to brain tissue in vivo explains beneficial effect of hypothermia in ischemia. In: Tomita M, Kanno I, Hamel E (Eds.), Brain Activation and CBF Control, Elsevier, Tokyo, pp.223-229.
Cumming P, Wong DF, Dannals RF, Gillings N, Hilton J, Scheffel U, Gjedde A (2002) The competition between endogenous dopamine and radioligands for specific binding to dopamine receptors. Ann N Y Acad Sci 965: 440-450.
Rosa Neto P, Lou H, Cumming P, Pryds O, Gjedde A (2002) Methylphenidate-evoked potentiation of extracellular dopamine in the brain of adolescents with premature birth: correlation with attentional deficit. Ann N Y Acad Sci 965: 434-439.
Gjedde A (2003) Da videnskabskrigen kom til Danmark: Den medicinske virkelighed kontra den humanistiske relativisme. Bibl Læger 195: 252—255.
Sakoh M, Ohnishi T, Ostergaard L, Gjedde A (2003) Prediction of tissue survival after stroke based on changes in the apparent diffusion of water (cytotoxic edema). Acta Neurochir (Suppl) 86: 137—140.
Gjedde A, Reith J, Wong DF (1995) Dopamine receptors in schizophrenia. Lancet 346: 1302-1303.
Gjedde A (1995) Origins of the Patlak plot. Nucl Med Comm 16: 979-980.
Gjedde A, Reith J, Wong DF (1996) In schizophrenia, some dopamine D-2-like receptors are still elevated. Psychiat Res: Neuroimage 67: 159-161.
Gjedde A, Wong DF (1997) Reaction volume concept - reply. J Nucl Med 38:341-342
Gjedde A (1997) Dark origins of the patlak-gjedde- blasberg-fenstermacher-rutland-rehling plot. Nuclear Medicine Communications 18: 274-275
Hermansen F. Poulsen PH. Danielsen E. Smith DF. Gee AD. Hansen SB. Gjedde A (1997) Parametric imaging of irreversible binding of C-11-NMSP requires weighted patlak analysis (vol 5, pg a30, 1997). Neuroimage 6: 230
Cumming P, Gjedde A, Reith J (1997) Controversies arising from recent fdopa articles. J Nucl Med 38: 1267-1269
Gjedde A (1998) Biparietale udfald ved Alzheimers sygdom. [Biparietal failure in Alzheimer’s disease] Ugeskr Laeger 160: 3236-3237
Gjedde A (1999) Peer review eller lodtraekning? [Peer review or lottery?] Ugeskr Laeger 161: 279
Cumming P, Hermansen F, Gjedde A (1999) Cerebral dopamine concentrations during levodopa treatment. Neurology 53: 1374-1375
Gjedde A (2001) [Normal weight contra ideal weight]. Ugeskr Laeger 163: 3822-3824
Gjedde A (2002) Metabolism of neurons and glia. Nature Reviews Neuroscience doi: 10.1038/nrn730-c1. Published online 29 November 2002.
Gjedde A (1971) Peter Ludvig Panums videnskabelige indsats [Scientific Accomplishments of Peter Ludvig Panum]. Bibliotek for Læger, Copenhagen: DadL.
Møller-Christensen V, Gjedde A (1979) The medical school in Copenhagen from its start in 1479 to its union with the academy of surgeons in 1842 (in Danish: Det lægevidenskabelige Fakultet l479-1842). In: Københavns Universitet 1479-1979 (eds. Melchior J et al.), vol. 7, pp. 1-89.
Gjedde A (1989) The emancipation of Miss Menten. J Cereb Blood Flow Metab 9: 243-246.
Gjedde A (1992) The Bohr effect is properly ascribed to Bohr. News Physiol Sci 7: 284-286.
Gjedde A (1993) In memoriam: Christian Crone (1926-1990) J Cereb Blood Flow Metab 13: 3-4.
Friberg L, Gjedde A (1997) In memoriam - Lassen, Niels A. - 7 December 1926 30 April 1997. Eur J Nucl Med 24: 1083-1084
Gjedde A (2004) Christian Bohr and the Seven Little Devils. Dansk Medicinsk-Historisk Årbog, pp. 13-40.